Pawpaw is best suited for rich, moist woodland settings or sheltered garden spaces. It prefers part shade when young and can tolerate more sun as it matures. Because it forms colonies, it is better suited for larger spaces or naturalized plantings rather than tight garden beds. It produces unique maroon flowers in spring, followed by large fruits in late summer with a tropical-like flavour.

Pawpaw is slow to establish, particularly during the first few years, while developing its extensive root system. It is often not self-fertile. Planting two or more genetically different trees improves the likelihood of fruit production. Hand-pollination may improve fruit set in some gardens. Fruit ripens quickly once it begins to soften, so check regularly in late summer. Large, soft leaves can become tattered or unattractive later in the season; this is normal and not usually a sign of a problem. Protect young trees from deer and rabbits if browsing is common. Avoid moving established trees—their fleshy, brittle roots make transplanting difficult.